Naserzadeh, P. and Ansari Esfeh, F. and Kaviani, M. and Ashtari, K. and Kheirbakhsh, R. and Salimi, A. and Pourahmad, J. (2018) Single-walled carbon nanotube, multi-walled carbon nanotube and Fe2O3 nanoparticles induced mitochondria mediated apoptosis in melanoma cells. Cutaneous and Ocular Toxicology, 37 (2). pp. 157-166.
Full text not available from this repository.Abstract
Purpose: Nanomaterials (NM) exhibit novel anticancer properties. Materials and methods: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. Results: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling, and cytochrome c release. The pretreatment of butylated hydroxytoluene (BHT), a cell-permeable antioxidant and cyclosporine A (Cs. A), a mitochondrial permeability transition (MPT), pore sealing agent decreased cytotoxicity, caspase 3 activation, ROS generation, and mitochondrial damages induced by SWCNT, MWCNT, and IONPs. Conclusions: Our promising results provide a potential approach for the future therapeutic use of SWCNT, MWCNT, and IONPs in melanoma through mitochondrial targeting. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 2 |
| Uncontrolled Keywords: | antioxidant; caspase 3; caspase 8 inhibitor; cyclosporine; cytochrome c; ferric oxide; iron nanoparticle; multi walled nanotube; reactive oxygen metabolite; single walled nanotube; succinate dehydrogenase, apoptosis; Article; cell permeabilization; cell viability; cytotoxicity; enzyme activation; melanoma; melanoma cell; mitochondrial membrane potential; mitochondrial permeability; mitochondrion; mitochondrion swelling; premedication; toxicity |
| Subjects: | WR Dermatology |
| Depositing User: | eprints admin |
| Date Deposited: | 29 Dec 2018 06:35 |
| Last Modified: | 29 Dec 2018 06:35 |
| URI: | http://eprints.iums.ac.ir/id/eprint/5942 |
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