High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals

Izadi, M.R. and Ghardashi Afousi, A. and Asvadi Fard, M. and Babaee Bigi, M.A. (2018) High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals. Journal of Physiology and Biochemistry, 74 (1). pp. 47-55.

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Hypertension is the major risk factor for cardiovascular diseases and is one of the primary causes of morbidity and mortality worldwide. Apelin levels and NO bioavailability are impaired in older hypertensive patients. Exercise is an effective intervention for treating hypertension. Our purpose was to evaluate the effect of high-intensity interval training on blood pressure, apelin, and NOx plasma levels in older treated hypertensive individuals. Thirty treated hypertensive subjects (61.70 ± 5.78 years, 17 males, 13 females) were randomly divided into 6 weeks of high-intensity interval training (n = 15) and control (n = 15). The exercise training was conducted for three 35-min sessions a week (1.5-min interval at 85�90 of heart rate reserve HRR and 2 min active phase at 50�55% of HRR). Assessment of plasma apelin, nitrite/nitrate (NOx), and endothelin-1 (ET-1) was performed before and after the intervention. At the end of the study, apelin, and NOx plasma levels increased significantly in the high-intensity interval training (HIIT) group (P = 0.021, P = 0.003, respectively). Conversely, ET-1 plasma levels significantly decreased in the training group after the intervention (P = 0.015). Moreover, there was a positive correlation between the change of plasma apelin and change of plasma NOx (r = 0. 771, P = 0.0008). In addition, there was a negative correlation between the change of plasma ET-1, change of plasma apelin (r = � 0.595, P = 0.019), and variation of NOx (r = � 0.572, P = 0.025). This study indicates that, by increasing of apelin and NOx plasma levels, HIIT may be effective in reducing blood pressure. © 2017, University of Navarra.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: apelin; endothelin 1; nitric oxide; antihypertensive agent; apelin; biological marker; nitric oxide, adult; aged; anthropometric parameters; Article; biochemical analysis; blood pressure regulation; cardiovascular parameters; clinical article; clinical assessment; controlled study; correlational study; diastolic blood pressure; exercise test; female; heart rate reserve; high intensity interval training; human; hypertension; male; protein blood level; randomized controlled trial; systolic blood pressure; treatment duration; aging; blood; blood pressure; follow up; heart rate; hypertension; metabolism; middle aged; multimodality cancer therapy; oxygen consumption; pathophysiology; patient compliance; severity of illness index, Aged; Aging; Antihypertensive Agents; Apelin; Biomarkers; Blood Pressure; Combined Modality Therapy; Female; Follow-Up Studies; Heart Rate; High-Intensity Interval Training; Humans; Hypertension; Lost to Follow-Up; Male; Middle Aged; Nitric Oxide; Oxygen Consumption; Patient Compliance; Severity of Illness Index
Subjects: WH Hemic and Lymphatic Systems
Depositing User: eprints admin
Date Deposited: 30 Dec 2018 10:41
Last Modified: 24 Aug 2019 03:56
URI: http://eprints.iums.ac.ir/id/eprint/5962

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