Artimani, T. and Karimi, J. and Mehdizadeh, M. and Yavangi, M. and Khanlarzadeh, E. and Ghorbani, M. and Asadi, S. and Kheiripour, N. (2018) Evaluation of pro-oxidant-antioxidant balance (PAB) and its association with inflammatory cytokines in polycystic ovary syndrome (PCOS). Gynecological Endocrinology, 34 (2). pp. 148-152.
Full text not available from this repository.Abstract
Chronic low-grade inflammation has been suggested as a key contributor of the pathogenesis and development of polycystic ovary syndrome (PCOS). To investigate the association between oxidative stress status and inflammatory cytokines in follicular fluid of 21 PCOS women compared to 21 women with normal ovarian function who underwent intra-cytoplasmic sperm injection. Concentration of IL-6, IL-8, IL-10, and TNF-α was measured using sandwich ELISA. Oxidative stress was examined by measuring total oxidant status (TOS), malondialdehyde (MDA), total antioxidant capacity (TAC), and thiol groups. PCOS women had an elevated concentration of MDA and TOS compared to controls. Levels of TAC and thiol groups were lower in PCOS compared to controls. PCOS patients had a higher concentration of IL-6, IL-8, and TNF-α compared to controls. Concentration of IL-10 was lower in PCOS compared to controls. Significant correlations were found between MDA and TOS concentration with TNF-α and between IL-6 and MDA, IL-8 and TAC, IL-10 and TOS levels and also between IL-10 and TAC levels. TAC and thiol groups were negatively correlated with TNF-α. Increased oxidative stress in PCOS is associated with inflammation which is closely linked. Inflammation can induce production of inflammatory cytokines in this syndrome and directly stimulates excess ovarian androgen production. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | human monoclonal antibody; interleukin 10; interleukin 6; interleukin 8; malonaldehyde; thiol group; tumor necrosis factor; biological marker; IL10 protein, human; IL6 protein, human; IL8 protein, human; interleukin 10; interleukin 6; interleukin 8; TNF protein, human; tumor necrosis factor, adult; androgen synthesis; Article; clinical article; controlled study; cross-sectional study; cytokine production; enzyme immunoassay; enzyme linked immunosorbent assay; female; human; inflammation; intracytoplasmic sperm injection; ovary follicle fluid; ovary function; ovary polycystic disease; oxidative stress; priority journal; prooxidant antioxidant balance; down regulation; female infertility; immunology; Iran; metabolism; middle aged; ovary; ovary polycystic disease; oxidative stress; pathophysiology; university hospital; upregulation, Adult; Biomarkers; Cross-Sectional Studies; Down-Regulation; Female; Follicular Fluid; Hospitals, University; Humans; Infertility, Female; Interleukin-10; Interleukin-6; Interleukin-8; Iran; Middle Aged; Ovary; Oxidative Stress; Polycystic Ovary Syndrome; Sperm Injections, Intracytoplasmic; Tumor Necrosis Factor-alpha; Up-Regulation |
| Subjects: | WP Gynecology QV Pharmacology |
| Depositing User: | eprints admin |
| Date Deposited: | 31 Dec 2018 07:08 |
| Last Modified: | 31 Dec 2018 07:08 |
| URI: | http://eprints.iums.ac.ir/id/eprint/6096 |
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