Effects of Selenium Supplementation on Gene Expression Levels of Inflammatory Cytokines and Vascular Endothelial Growth Factor in Patients with Gestational Diabetes

Jamilian, M. and Samimi, M. and Afshar Ebrahimi, F. and Aghadavod, E. and Mohammadbeigi, R. and Rahimi, M. and Asemi, Z. (2018) Effects of Selenium Supplementation on Gene Expression Levels of Inflammatory Cytokines and Vascular Endothelial Growth Factor in Patients with Gestational Diabetes. Biological Trace Element Research, 181 (2). pp. 199-206.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Selenium is known to exert multiple beneficial effects including anti-inflammatory actions. The aim of the study was to evaluate the effects of selenium supplementation on gene expression levels of inflammatory cytokines and vascular endothelial growth factor (VEGF) in women with gestational diabetes (GDM). This randomized double-blind, placebo-controlled trial was carried out among 40 subjects diagnosed with GDM aged 18�40 years old. Subjects were randomly allocated into two groups to receive either 200 μg/day selenium supplements (n = 20) or placebo (n = 20) for 6 weeks. Gene expression of inflammatory cytokines and VEGF were assessed in lymphocytes of GDM women with RT-PCR method. Results of RT-PCR indicated that after the 6-week intervention, compared with the placebo, selenium supplementation downregulated gene expression of tumor necrosis factor alpha (TNF-α) (P = 0.02) and transforming growth factor beta (TGF-β) (P = 0.01), and upregulated gene expression of VEGF (P = 0.03) in lymphocytes of patients with GDM. There was no statistically significant change following supplementation with selenium on gene expression of interleukin (IL)-1β and IL-8 in lymphocytes of subjects with GDM. Selenium supplementation for 6 weeks in women with GDM significantly decreased gene expression of TNF-α and TGF-β, and significantly increased gene expression of VEGF, but did not affect gene expression of IL-1β and IL-8. Clinical trial registration number http://www.irct.ir: IRCT201612045623N95. © 2017, Springer Science+Business Media New York.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: placebo; selenium; cytokine; selenium; vasculotropin, adult; Article; clinical article; controlled study; down regulation; female; gene; gene expression regulation; human; human cell; IL 1beta gene; IL 8 gene; inflammation; lymphocyte; pregnancy diabetes mellitus; randomized controlled trial; reverse transcription polymerase chain reaction; supplementation; TGF beta gene; TNF alpha gene; VEGF gene; adolescent; blood; dietary supplement; genetics; metabolism; pregnancy; pregnancy diabetes mellitus; real time polymerase chain reaction; young adult, Adolescent; Adult; Cytokines; Diabetes, Gestational; Dietary Supplements; Female; Humans; Inflammation; Pregnancy; Real-Time Polymerase Chain Reaction; Selenium; Vascular Endothelial Growth Factors; Young Adult
Subjects: WG Cardiovascular System
WQ Obstetrics
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 31 Dec 2018 07:58
Last Modified: 24 Aug 2019 05:04
URI: http://eprints.iums.ac.ir/id/eprint/6108

Actions (login required)

View Item View Item