Nasri, K. and Akrami, S. and Rahimi, M. and Taghizadeh, M. and Behfar, M. and Mazandaranian, M.R. and Kheiry, A. and Memarzadeh, M.R. and Asemi, Z. (2018) The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Endocrine Research, 43 (1). pp. 1-10.
Full text not available from this repository.Abstract
Purpose of the study: There was inconsistent evidence about the benefit of vitamin D plus evening primrose oil (EPO) supplement intake on lipid profiles and reduced oxidative stress among women with polycystic ovary syndrome (PCOS). The current study was performed to evaluate the effects of vitamin D plus EPO supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with PCOS. Materials and methods: This randomized, double-blind, placebo-controlled trial was performed among 60 vitamin D-deficient women with PCOS. Participants were randomly assigned into two groups to receive either 1000 IU vitamin D3 plus 1000 mg EPO (n = 30) or placebo (n = 30) for 12 weeks. Metabolic profiles were quantified at baseline and after the 12-week intervention. Results: Compared with the placebo group, women in vitamin D and EPO co-supplementation group had significant increases in serum 25-hydroxyvitamin D (25(OH)D) (+10.7 ± 8.4 vs. �0.5 ± 1.6 ng/mL, p < 0.001) and plasma total glutathione (GSH) (+62.7 ± 58.0 vs. �0.7 ± 122.7 µmol/L, p = 0.01), while there were significant decreases in triglycerides (�7.3 ± 23.8 vs. +6.9 ± 26.3 mg/dL, p = 0.03), very low-density lipoprotein (VLDL) cholesterol levels (�1.5 ± 4.7 vs. +1.4 ± 5.3 mg/dL, p = 0.03), total/high-density lipoprotein cholesterol ratio (�0.3 ± 0.4 vs. �0.02 ± 0.4, p = 0.02), and malondialdehyde (MDA) concentration (�0.4 ± 0.4 vs. +0.5 ± 1.8 µmol/L, p = 0.008). Conclusion: Overall, vitamin D and EPO co-supplementation for 12 weeks among vitamin D-deficient women with PCOS significantly improved triglycerides, VLDL cholesterol, GSH, and MDA levels. © 2017 Taylor & Francis.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | 25 hydroxyvitamin D; biological marker; colecalciferol; glutathione; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; malonaldehyde; metformin; placebo; primrose oil; thiobarbituric acid reactive substance; triacylglycerol; very low density lipoprotein cholesterol, acne; adult; age; alopecia; Article; biochemical analysis; body height; body mass; body weight; cholesterol blood level; clinical outcome; combination drug therapy; controlled study; double blind procedure; drug dose increase; drug efficacy; female; hirsutism; human; intervention study; low drug dose; major clinical study; medication compliance; metabolic parameters; ovary polycystic disease; oxidative stress; patient compliance; plasma; priority journal; quantitative analysis; randomized controlled trial; supplementation; triacylglycerol blood level; vitamin blood level; vitamin D deficiency |
| Subjects: | WQ Obstetrics |
| Depositing User: | eprints admin |
| Date Deposited: | 25 Dec 2018 16:09 |
| Last Modified: | 25 Dec 2018 16:09 |
| URI: | http://eprints.iums.ac.ir/id/eprint/6121 |
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