Expression analysis of apoptosis-related genes in bladder cancer patients

Yazarlou, F. and Afsharpad, M. and Oskooei, V.K. and Nekoohesh, L. and Moharrami, T. and Samadaian, N. and Ghafouri-Fard, S. and Modarressi, M.H. (2018) Expression analysis of apoptosis-related genes in bladder cancer patients. Meta Gene, 18. pp. 137-142.

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Background: Bladder cancer (BC) is a frequent cancer with high morbidity and mortality. Method: We assessed expression of NMP22, BAG3, BCL2 and BAX in BC samples, adjacent non-neoplastic tissues (ANNTs), urinary cell pellets (UCP) of the same patients and non-malignant conditions (NM). Results: NMP22 was up-regulated in tumoral tissues compared with ANNTs and in UCP of BC patients compared with UCP of NM. BCL2 and BAX were down-regulated in BC tissues compared with ANNTs. BAG3 and BAX were down-regulated in UCP of BC compared with NM. The combination of all four genes had 100 sensitivity and specificity for detection of BC in urine. Conclusion: Expression analysis of these genes in tumor or urine is a tool for detection of BC. © 2018

Item Type: Article
Additional Information: cited By 0
Subjects: WJ Urogenital System
QZ Pathology
Depositing User: eprints admin
Date Deposited: 25 Dec 2018 15:18
Last Modified: 25 Dec 2018 15:18

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