Effect of melissa officinalis (Lemon balm) on sexual dysfunction in women: A double- blind, randomized, placebo-controlled study

Darvish-Mofrad-Kashani, Z. and Emaratkar, E. and Hashem-Dabaghian, F. and Emadi, F. and Raisi, F. and Aliasl, J. and Kamalinejad, M. and Hasheminejad, S.A. and Eftekhar, T. and Zafarghandi, N. (2018) Effect of melissa officinalis (Lemon balm) on sexual dysfunction in women: A double- blind, randomized, placebo-controlled study. Iranian Journal of Pharmaceutical Research, 17 (Specia). pp. 89-100.


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Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual dysfunction (FSD) and its bio-psychosocial multifactorial etiology justifies its multifaceted treatment. In Persian Medicine (PM), the weakness of the main organs (heart, brain and liver) is one of the important causes of lack of sexual desire; hence, their strengthening is a priority during treatment. Melissa officinalis is one of the medicinal plants with tonic characteristics for the main organs in PM and was used for treatment in this study. The aim of the present study was to evaluate the efficacy and safety of M. officinalis in the improvement of HSDD in women. Eighty nine (89) eligible women suffering from decreased sexual desire were randomly assigned to groups. The participants received medication (500 mg of aqueous extract of M. officinalis) or placebo 2 times a day for 4 weeks. Changes in scores of desire, arousal, lubrication, orgasm, satisfaction and pain were evaluated at the end of 4 weeks of treatment using the Female Sexual Function Index (FSFI) questionnaire in the two groups. Forty three participants completed the study. The increase in desire (P < 0.001), arousal (P < 0.001), lubrication (P < 0.005), orgasm (P < 0.001), satisfaction (P < 0.001), pain (P < 0.002) and FSFI total score (P < 0.001) in the M. officinalis group was significantly more than that of the placebo group. The willingness to continue treatment was significantly higher in the M. officinalis as compared to the placebo group (P < 0.001). M. officinalis may be a safe and effective herbal medicine for the improvement of HSDD in women. © 2018 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Melissa officinalis extract; placebo, adult; Article; body mass; constipation; controlled study; diarrhea; double blind procedure; drug efficacy; drug safety; employment; female; female sexual dysfunction; Female Sexual Function Index; housewife; human; major clinical study; Melissa officinalis; nausea; orgasm; outcome assessment; pain assessment; randomized controlled trial; sexual arousal; sexual satisfaction; side effect; standardization; vagina bleeding; vagina discharge; vaginal lubrication
Subjects: WQ Obstetrics
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 25 Dec 2018 14:42
Last Modified: 01 Jul 2019 04:11
URI: http://eprints.iums.ac.ir/id/eprint/6159

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