Predictive factors of acute renal failure in the neonates with respiratory distress syndrome

Nickavar, A. and Choobdar, F.A. and Mazouri, A. and Talebi, A. (2018) Predictive factors of acute renal failure in the neonates with respiratory distress syndrome. Iranian Journal of Neonatology, 9 (1). pp. 1-6.

IJN_Volume 9_Issue 1_Pages 1-6.pdf

Download (769kB) | Preview
Official URL:


Background: Preterm birth occurs in a large number of pregnancies, and its incidence has been reported to be on the rise. Acute kidney injury (AKI) is a common complication in the premature infants with respiratory distress syndrome (RDS). The present study aimed to determine the predictive factors, clinical courses, and outcomes of AKI in the neonates with the clinical and radiological manifestations of RDS. Methods: Medical records of 84 premature neonates with RDS were evaluated in two groups of case (with AKI) (n=34) and control (without AKI) (n=50). Diagnosis of AKI was based on the increased level of serum creatinine (>1.5 mg/dL) after the third day of birth or increasing serum creatinine level. In addition, blood pressure and laboratory findings, including complete blood count, serum electrolytes, and urine volume, were compared between the two groups. Results: Mean age of the infants with AKI was 5.41±3.29 days, and the majority of the patients had nonoliguric renal failure. Among the samples, 23.5 died, and 76.5 were discharged without renal impairment. Birth weight, systolic blood pressure, blood urea nitrogen, calcium, and pH on admission had significant correlations with the presence of AKI. Moreover, birth weight was observed to be a relatively accurate predictive factor for AKI (AUC=0.08; 95 CI=0.68-0.91), with 73.5 sensitivity and 80 specificity. Conclusion: According to the results, AKI was more common in the low-birth-weight infants with severe RDS compared to the other subjects. © 2018 Mashhad University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: calcium; creatinine; electrolyte; nitrogen; urea, acute kidney failure; Article; birth weight; blood cell count; calcium blood level; cause of death; clinical evaluation; clinical feature; controlled study; creatinine blood level; cross-sectional study; disease course; electrolyte blood level; female; hospital discharge; human; infant; major clinical study; male; medical record; newborn; outcome assessment; pH measurement; prediction; prematurity; respiratory distress syndrome; sensitivity and specificity; systolic blood pressure; urea nitrogen blood level; urine volume
Subjects: WF Respiratory System
WJ Urogenital System
WS Pediatrics
Depositing User: eprints admin
Date Deposited: 25 Dec 2018 14:23
Last Modified: 30 Jun 2019 06:27

Actions (login required)

View Item View Item