Jamilian, M. and Samimi, M. and Mirhosseini, N. and Afshar Ebrahimi, F. and Aghadavod, E. and Talaee, R. and Jafarnejad, S. and Hashemi Dizaji, S. and Asemi, Z. (2018) The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. Journal of Affective Disorders, 238. pp. 32-38.
Full text not available from this repository.Abstract
Objective: The aim of this study was to evaluate the effect of the co-administration of vitamin D and omega-3 fatty acid on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome (PCOS). Methods: This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18�40 years old with PCOS. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 2000 mg/day omega-3 fatty acid from fish oil (n = 30) or placebo (n = 30) for 12 weeks. Gene expression analysis of inflammatory cytokines was conducted on peripheral blood mononuclear cells (PBMCs) of PCOS women using RT-PCR method. Results: Vitamin D and omega -3 fatty acid co-supplementation significantly decreased serum total testosterone levels (�0.2 ± 0.5 vs. + 0.1 ± 0.4 ng/mL, P = 0.02) compared with the placebo. In addition, vitamin D and omega-3 fatty acid co-supplementation resulted in a significant improvement in beck depression inventory (�1.4 ± 1.6 vs. �0.5 ± 0.6, P = 0.01), general health questionnaire scores (�4.5 ± 4.3 vs. �1.9 ± 2.3, P = 0.005) and depression anxiety and stress scale scores (�5.0 ± 5.1 vs. �2.3 ± 3.5, P = 0.01) compared with the placebo. Additionally, vitamin D and omega-3 fatty acid co-administration significantly decreased serum high-sensitivity C-reactive protein (hs-CRP) (�1.2 ± 1.9 vs. + 0.1 ± 0.7 mg/L, P = 0.001) and malondialdehyde (MDA) levels (�0.4 ± 0.4 vs. + 0.2 ± 0.6 µmol/L, P < 0.001), and significantly increased plasma total antioxidant capacity (TAC) levels (+ 114.6 ± 122.2 vs. -2.4 ± 168.2 mmol/L, P = 0.003) compared with the placebo. Results of RT-PCR demonstrated that vitamin D and omega-3 fatty acid co-supplementation significantly downregulated gene expression of interleukin-1 (IL-1) (P = 0.03), and upregulated vascular endothelial growth factor (VEGF) (P = 0.004) in PBMCs of subjects with PCOS, when compared with placebo. Conclusions: Overall, the co-administration of vitamin D and omega-3 fatty acid for 12 weeks had beneficial effects on mental health parameters, serum total testosterone, hs-CRP, plasma TAC and MDA levels, and gene expression of IL-1 and VEGF among women with PCOS. © 2018 Elsevier B.V.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | androgen; antioxidant; C reactive protein; fish oil; glutathione; interleukin 1; interleukin 8; malonaldehyde; nitric oxide; omega 3 fatty acid; placebo; sex hormone binding globulin; testosterone; transforming growth factor beta; tumor necrosis factor; vasculotropin; vitamin D, adult; androgen blood level; Article; Beck Depression Inventory; biochemistry; cell isolation; comparative study; controlled study; Depression Anxiety Stress Scale; double blind procedure; down regulation; drug effect; endothelial dysfunction; evaluation study; female; gene expression; General Health Questionnaire; genetic analysis; genetic parameters; human; immunomodulation; inflammation; major clinical study; mental disease; metabolic parameters; ovary polycystic disease; peripheral blood mononuclear cell; priority journal; protein blood level; quantitative assay; randomized controlled trial; real time polymerase chain reaction; RNA extraction; supplementation; testosterone blood level; upregulation; vitamin blood level |
| Subjects: | WP Gynecology QV Pharmacology QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 25 Dec 2018 12:35 |
| Last Modified: | 19 Aug 2019 10:04 |
| URI: | http://eprints.iums.ac.ir/id/eprint/6209 |
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