Clofazimine: A useful antibiotic for drug-resistant tuberculosis

Mirnejad, R. and Asadi, A. and Khoshnood, S. and Mirzaei, H. and Heidary, M. and Fattorini, L. and Ghodousi, A. and Darban-Sarokhalil, D. (2018) Clofazimine: A useful antibiotic for drug-resistant tuberculosis. Biomedicine and Pharmacotherapy, 105. pp. 1353-1359.

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Drug resistance is still the major threat to global tuberculosis (TB) control, and drug-resistant (DR) Mycobacterium tuberculosis (M. tuberculosis) strains have become the main challenge worldwide. Currently used antibiotics for treatment of DR-TB are often poorly tolerated and not sufficiently effective. Since the therapeutic options are still limited, the main strategy for treatment of DR-TB is to repurpose existing anti-mycobacterial agents. Clofazimine (CFZ) is one such drug that has recently attracted interest against DR-TB. CFZ is a hydrophobic riminophenazine that was initially synthesized as an anti-TB antibiotic. Although the mechanisms of action of CFZ are not yet entirely understood, it has been suggested that outer membrane is its primary action site, and the respiratory chain and ion transporters are the putative targets. In this review, we will discuss the anti-mycobacterial properties of CFZ, and provide new insights into the clinical use of this drug. © 2018 Elsevier Masson SAS

Item Type: Article
Additional Information: cited By 0
Subjects: WF Respiratory System
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 10:47
Last Modified: 24 Dec 2018 10:47

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