Trigonelline mitigates lipopolysaccharide-induced learning and memory impairment in the rat due to its anti-oxidative and anti-inflammatory effect

Khalili, M. and Alavi, M. and Esmaeil-Jamaat, E. and Baluchnejadmojarad, T. and Roghani, M. (2018) Trigonelline mitigates lipopolysaccharide-induced learning and memory impairment in the rat due to its anti-oxidative and anti-inflammatory effect. International Immunopharmacology, 61. pp. 355-362.

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Brain inflammation is associated with cognitive dysfunction, especially in elderly. Trigonelline is a plant alkaloid and a major component of coffee and fenugreek with anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. In this study, the beneficial effect of trigonelline against lipopolysaccharide (LPS)-induced cognitive decline was assessed in the rat. LPS was injected i.p. at a dose of 500 μg/kg to induce neuroinflammation and trigonelline was administered p.o. at doses of 20, 40, or 80 mg/kg/day 1 h after LPS that continued for one week. Trigonelline-treated LPS-challenged rats showed improved spatial recognition memory in Y maze, discrimination ratio in novel object discrimination test, and retention and recall in passive avoidance paradigm. Additionally, trigonelline lowered hippocampal malondialdehyde (MDA) and acetylcholinesterase (AChE) activity and improved superoxide dismutase (SOD), catalase, and glutathione (GSH). Furthermore, trigonelline depressed hippocampal nuclear factor-kappaB (NF-κB), toll-like receptor 4 (TLR4), and tumor necrosis factor α (TNF α) in LPS-challenged rats. All of the effects of trigonelline followed a dose-dependent pattern and in some aspects, it acted even better than the routinely-used anti-inflammatory drug dexamethasone. Collectively, trigonelline is capable to diminish LPS-induced cognitive decline via suppression of hippocampal oxidative stress and inflammation and appropriate modulation of NF-κB/TLR4 and AChE activity. © 2018 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: acetylcholinesterase; catalase; dexamethasone; glutathione; immunoglobulin enhancer binding protein; malonaldehyde; superoxide dismutase; toll like receptor 4; trigonelline; tumor necrosis factor, animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; controlled study; dose response; drug mechanism; enzyme activity; hippocampus; learning disorder; lipid peroxidation; lipopolysaccharide-induced neuroinflammation; male; memory disorder; nonhuman; novel object recognition test; oxidative stress; passive avoidance; passive avoidance test; priority journal; rat; recognition; spatial memory; T-maze test; task performance
Subjects: WL Nervous System
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 07:36
Last Modified: 18 Aug 2019 08:40

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