Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy

Keshavarz, M. and Moloudi, K. and Paydar, R. and Abed, Z. and Beik, J. and Ghaznavi, H. and Shakeri-Zadeh, A. (2018) Alginate hydrogel co-loaded with cisplatin and gold nanoparticles for computed tomography image-guided chemotherapy. Journal of Biomaterials Applications, 33 (2). pp. 161-169.

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The biomedical applications of gold nanoparticles (AuNPs) have experienced rapid growth in recent years, due to their expected benefits in medical imaging and therapy. In this work, we report the development of a theranostic nanocomplex constructed from alginate hydrogel co-loaded with cisplatin and AuNPs (abbreviated as ACA) for simultaneous drug delivery and computed tomography imaging. CT26 cells derived from mouse colon adenocarcinoma were exposed to various concentrations of ACA nanocomplex (for 24 h) and the cytotoxicity was measured using MTT assay. Moreover, the cells treated with ACA nanocomplex were imaged in a computed tomography scanner and the contrast enhancement due to the presence of nanocomplex was assessed. The cytotoxicity results showed that ACA nanocomplex had a more potent chemotherapy efficacy than free cisplatin, so that ACA nanocomplex at the concentration of 5 µg/ml (per cisplatin) and 20 µg/ml of free cisplatin resulted in the same cytotoxicity (survival rate: 66). The computed tomography imaging study revealed that ACA nanocomplex increased the brightness of computed tomography images, the computed tomography number value, and contrast-to-noise ratio (CNR). ACA nanocomplex can be presented as a computed tomography-traceable nanocarrier that allows to monitor the delivery of therapeutics by assessing their localized accumulation and in vivo biodistribution. © The Author(s) 2018.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Alginate; Chemotherapy; Controlled drug delivery; Cytotoxicity; Enzyme inhibition; Fiber optic sensors; Gold nanoparticles; Hydrogels; Image enhancement; Medical applications; Medical imaging; Metal nanoparticles; Targeted drug delivery, Alginate hydrogels; Biomedical applications; Cis-platin; Computed tomography images; Computed tomography scanners; Contrast Enhancement; Contrast to noise ratio; Theranostics, Computerized tomography
Subjects: QV Pharmacology
QZ Pathology
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 07:22
Last Modified: 24 Dec 2018 07:22

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