The effects of magnesium and vitamin e co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes

Maktabi, M. and Jamilian, M. and Amirani, E. and Chamani, M. and Asemi, Z. (2018) The effects of magnesium and vitamin e co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes. Lipids in Health and Disease, 17 (1).


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Background: Magnesium and vitamin E are known to exert multiple beneficial effects, such as anti-glycemic and anti-lipidemic properties. The aim of this study was to determine the effects of magnesium and vitamin E co-supplementation on metabolic status of women with gestational diabetes (GDM). Methods: This randomized, double-blinded, placebo-controlled trial was conducted among 60 subjects diagnosed with GDM, aged 18-40 years. Subjects were randomly allocated into two groups to receive 250 mg/day magnesium oxide plus 400 IU/day vitamin E supplements or placebo (n = 30 each group) for 6 weeks. Participants' blood samples were taken to determine their metabolic profiles. Results: Subjects who received magnesium plus vitamin E supplements had significantly lower fasting plasma glucose (β - 5.20 mg/dL; 95 CI, - 7.88, - 2.52; P = 0.002), serum insulin levels (β - 2.93 μIU/mL; 95 CI, - 5.68, - 0.18; P = 0.02) and homeostasis model of assessment-insulin resistance (β - 0.78; 95 CI, - 1.42, - 0.14; P = 0.01), and higher quantitative insulin sensitivity check index (β 0.01; 95 CI, 0.005, 0.02; P = 0.002) compared with placebo. In addition, magnesium plus vitamin E supplementation resulted in a significant reduction in serum triglycerides (β - 50.31 mg/dL; 95 CI, - 67.58, - 33.04; P < 0.001), VLDL- (β - 10.06 mg/dL; 95 CI, - 13.51, - 6.60; P < 0.001), total- (β - 26.10 mg/dL; 95 CI, - 41.88, - 10.33; P = 0.004), LDL- (β - 15.20 mg/dL; 95 CI, - 29.50, - 0.91; P = 0.03) and total-/HDL-cholesterol ratio (β - 0.46; 95 CI, - 0.72, - 0.19; P < 0.001) compared with placebo. Magnesium and vitamin E co-supplementation did not affect HDL-cholesterol levels. Conclusions: Overall, magnesium and vitamin E co-supplementation for 6 weeks in women with GDM significantly improved glycemic control and lipid profiles, except for HDL-cholesterol levels. Clinical trial registration number: IRCT20170513033941N24. © 2018 The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: alpha tocopherol; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; magnesium oxide; placebo; triacylglycerol; very low density lipoprotein cholesterol, adult; Article; blood sampling; cholesterol blood level; controlled study; double blind procedure; drug efficacy; female; glucose blood level; glucose homeostasis; glycemic control; homeostasis model assessment; human; insulin blood level; lipid analysis; major clinical study; metabolism; pregnancy diabetes mellitus; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; total cholesterol level; triacylglycerol blood level; vitamin supplementation
Subjects: WB Practice of Medicine
WQ Obstetrics
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 06:59
Last Modified: 02 Jul 2019 10:27

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