Maktabi, M. and Jamilian, M. and Amirani, E. and Chamani, M. and Asemi, Z. (2018) The effects of magnesium and vitamin e co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes. Lipids in Health and Disease, 17 (1).
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The-effects-of-magnesium-and-vitamin-e-cosupplementation-on-parameters-of-glucose-homeostasis-and-lipid-profiles-in-patients-with-gestational-diabetes2018Lipids-in-Health-and-DiseaseOpen-Access.pdf Download (484kB) | Preview |
Abstract
Background: Magnesium and vitamin E are known to exert multiple beneficial effects, such as anti-glycemic and anti-lipidemic properties. The aim of this study was to determine the effects of magnesium and vitamin E co-supplementation on metabolic status of women with gestational diabetes (GDM). Methods: This randomized, double-blinded, placebo-controlled trial was conducted among 60 subjects diagnosed with GDM, aged 18-40 years. Subjects were randomly allocated into two groups to receive 250 mg/day magnesium oxide plus 400 IU/day vitamin E supplements or placebo (n = 30 each group) for 6 weeks. Participants' blood samples were taken to determine their metabolic profiles. Results: Subjects who received magnesium plus vitamin E supplements had significantly lower fasting plasma glucose (β - 5.20 mg/dL; 95 CI, - 7.88, - 2.52; P = 0.002), serum insulin levels (β - 2.93 μIU/mL; 95 CI, - 5.68, - 0.18; P = 0.02) and homeostasis model of assessment-insulin resistance (β - 0.78; 95 CI, - 1.42, - 0.14; P = 0.01), and higher quantitative insulin sensitivity check index (β 0.01; 95 CI, 0.005, 0.02; P = 0.002) compared with placebo. In addition, magnesium plus vitamin E supplementation resulted in a significant reduction in serum triglycerides (β - 50.31 mg/dL; 95 CI, - 67.58, - 33.04; P < 0.001), VLDL- (β - 10.06 mg/dL; 95 CI, - 13.51, - 6.60; P < 0.001), total- (β - 26.10 mg/dL; 95 CI, - 41.88, - 10.33; P = 0.004), LDL- (β - 15.20 mg/dL; 95 CI, - 29.50, - 0.91; P = 0.03) and total-/HDL-cholesterol ratio (β - 0.46; 95 CI, - 0.72, - 0.19; P < 0.001) compared with placebo. Magnesium and vitamin E co-supplementation did not affect HDL-cholesterol levels. Conclusions: Overall, magnesium and vitamin E co-supplementation for 6 weeks in women with GDM significantly improved glycemic control and lipid profiles, except for HDL-cholesterol levels. Clinical trial registration number: http://www.irct.ir: IRCT20170513033941N24. © 2018 The Author(s).
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | alpha tocopherol; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; magnesium oxide; placebo; triacylglycerol; very low density lipoprotein cholesterol, adult; Article; blood sampling; cholesterol blood level; controlled study; double blind procedure; drug efficacy; female; glucose blood level; glucose homeostasis; glycemic control; homeostasis model assessment; human; insulin blood level; lipid analysis; major clinical study; metabolism; pregnancy diabetes mellitus; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; total cholesterol level; triacylglycerol blood level; vitamin supplementation |
| Subjects: | WB Practice of Medicine WQ Obstetrics |
| Depositing User: | eprints admin |
| Date Deposited: | 24 Dec 2018 06:59 |
| Last Modified: | 02 Jul 2019 10:27 |
| URI: | http://eprints.iums.ac.ir/id/eprint/6360 |
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