Metabolic syndrome and the iodine-dose/creatinine clearance ratio as determinants of contrast-induced acute kidney injury

Amiri, A. and Ghanavati, R. and Riahi Beni, H. and Sezavar, S.H. and Sheykhvatan, M. and Arab, M. (2018) Metabolic syndrome and the iodine-dose/creatinine clearance ratio as determinants of contrast-induced acute kidney injury. CardioRenal Medicine, 8 (3). pp. 217-227.

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Background: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated. Methods: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group. All patients were assessed for the development of CI-AKI after the procedures. Results: CI-AKI occurred in 39.23 (51 of 130) of the MetS patients and 14.4 (18 of 125) of the control group (p < 0.001). The multivariable regression model showed that male sex and the use of statins decreased the risk of CI-AKI, and high triglyceride levels, I-dose/CrCl > 0.52, MetS, CrCl �60 mL/min, and age �70 years increased the risk of CI-AKI, independent of confounding factors. The difference in the mean V/CrCl ratio was statistically significant between patients who developed CI-AKI and those who did not show renal impairment (2.36 ± 1.35 vs. 1.43 ± 0.89, respectively; p < 0.001). The ROC curve analysis of I-dose/CrCl determined the best cutoff value for patients with and those without MetS as 0.51 and 0.63, with a sensitivity value of 68 and 72 and a specificity value of 73 and 74, respectively. Conclusions: We showed that MetS is a strong risk factor for CI-AKI in nondiabetic patients undergoing elective coronary interventions; and the I-dose/CrCl ratio is a strong predictor of CI-AKI in these patients. We suggest that clinicians identify MetS patients and calculate their I-dose/CrCl ratio before coronary interventions. © 2018 S. Karger AG, Basel. Copyright: All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; iodine; low density lipoprotein cholesterol, abdominal obesity; acute kidney failure; adult; aged; Article; cohort analysis; contrast induced nephropathy; controlled study; coronary angiography; creatinine clearance; eosinophilia; female; follow up; glomerulus filtration rate; glucose blood level; human; hypertension; livedo reticularis; major clinical study; male; metabolic syndrome X; middle aged; priority journal; prospective study; risk factor; sensitivity and specificity; triacylglycerol level; waist circumference
Subjects: WJ Urogenital System
Depositing User: eprints admin
Date Deposited: 23 Dec 2018 10:30
Last Modified: 18 Aug 2019 06:40

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