Ostadmohammadi, V. and Samimi, M. and Mobini, M. and Zarezade Mehrizi, M. and Aghadavod, E. and Chamani, M. and Dastorani, M. and Asemi, Z. (2018) The effect of zinc and vitamin E cosupplementation on metabolic status and its related gene expression in patients with gestational diabetes. Journal of Maternal-Fetal and Neonatal Medicine. pp. 1-8.
Full text not available from this repository.Abstract
Objective: The aim of this study was to determine the effects of zinc and vitamin E cosupplementation on metabolic status and gene expression related to insulin and lipid metabolism in women with gestational diabetes mellitus (GDM). Methods: Fifty-four women, in the age range of 18�40 years, diagnosed with GDM were recruited for this randomized, double-blinded, placebo-controlled trial. Subjects were randomly allocated into two intervention groups to either taking 233�mg/day Zinc Gluconate plus 400-IU/day vitamin E supplements or placebo (n�=�27 each group) for 6 weeks. Gene expression related to insulin and lipid metabolism was evaluated in peripheral blood mononuclear cells (PBMCs) of women with GDM using RT-PCR method. Results: Participants who received zinc plus vitamin E supplements had significantly lower serum insulin levels (β�=��3.81; 95 CI, �5.90, �1.72; p�=�.001), homeostasis model of assessment-insulin resistance (β�=��0.96; 95 CI, �1.54, �0.38; p�=�.002), serum total-cholesterol (β�=��8.56; 95 CI, �16.69, �0.43; p�=�.03) and low density lipoprotein-cholesterol (LDL)-cholesterol (β�=��8.72; 95 CI, �15.27, �2.16; p�=�.01), and higher quantitative insulin sensitivity check index (β�=�0.01; 95 CI, 0.005, 0.02; p�=�.007) compared with the placebo. Moreover, zinc and vitamin E cosupplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ; p�=�.03) and low-density lipoprotein receptor (LDLR; p�=�.04) compared with the placebo. Though, zinc and vitamin E combination did not affect other metabolic parameters. Conclusions: Overall, zinc and vitamin E cosupplementation for 6 weeks in women with GDM significantly improved insulin metabolism, lipid profile, and the gene expression levels of PPAR-γ and LDLR. © 2018 Informa UK Limited, trading as Taylor & Francis Group
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0; Article in Press |
| Subjects: | WK Endocrine System WQ Obstetrics |
| Depositing User: | eprints admin |
| Date Deposited: | 23 Dec 2018 07:03 |
| Last Modified: | 23 Dec 2018 07:03 |
| URI: | http://eprints.iums.ac.ir/id/eprint/6485 |
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