Murru, E. and Carta, G. and Cordeddu, L. and Melis, M.P. and Desogus, E. and Ansar, H. and Chilliard, Y. and Ferlay, A. and Stanton, C. and Coakley, M. and Ross, R.P. and Piredda, G. and Addis, M. and Mele, M.C. and Cannelli, G. and Banni, S. and Manca, C. (2018) Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans. International Journal of Molecular Sciences, 19 (6).
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Dietary-conjugated-linoleic-acidenriched-cheeses-influence-the-levels-of-circulating-n3-highly-unsaturated-fatty-acids-in-humans2018International-Journal-of-Molecular-SciencesOpen-Access.pdf Download (1MB) | Preview |
Abstract
n-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance and the inflammatory response. We investigated changes to the n-3 HUFA score of healthy adults, induced by different types and amounts of conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for different periods of time, compared to dietary fish oil (FO) pills (500 mg, each containing 100 mg of eicosapentaenoic and docosahexaenoic acids�EPA+DHA) or α-linolenic acid (ALA)-rich linseed oil (4 g, containing 2 g of ALA). A significant increase in the n-3 HUFA score was observed, in a dose-dependent manner, after administration of the FO supplement. In terms of the impact on the n-3 HUFA score, the intake of ENCH cheese (90 g/day) for two or four weeks was equivalent to the administration of one or two FO pills, respectively. Conversely, the linseed oil intake did not significantly impact the n-3 HUFA score. Feeding ENCH cheeses from different sources (bovine, ovine and caprine) for two months improved the n-3 HUFA score by increasing plasma DHA, and the effect was proportional to the CLA content in the cheese. We suggest that the improved n-3 HUFA score resulting from ENCH cheese intake may be attributed to increased peroxisome proliferator-activated receptor alpha (PPAR-α) activity. This study demonstrates that natural ENCH cheese is an alternative nutritional source of n-3 HUFA in humans. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | fish oil; high density lipoprotein cholesterol; linoleic acid; linolenic acid; linseed oil; low density lipoprotein cholesterol; olive oil; palmitic acid; peroxisome proliferator activated receptor alpha; unsaturated fatty acid, adult; Article; body mass; cheese; controlled study; diet; energy balance; female; flame ionization detection; gene expression; high performance liquid chromatography; human; human experiment; lipid metabolism; liquid chromatography-mass spectrometry; male; milk; normal human; pilot study; real time polymerase chain reaction |
| Subjects: | WB Practice of Medicine |
| Depositing User: | eprints admin |
| Date Deposited: | 23 Dec 2018 07:07 |
| Last Modified: | 08 Jul 2019 10:08 |
| URI: | http://eprints.iums.ac.ir/id/eprint/6488 |
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