Stem Cell Tracing Through MR Molecular Imaging

Yahyapour, R. and Farhood, B. and Graily, G. and Rezaeyan, A. and Rezapoor, S. and Abdollahi, H. and Cheki, M. and Amini, P. and Fallah, H. and Najafi, M. and Motevaseli, E. (2018) Stem Cell Tracing Through MR Molecular Imaging. Tissue Engineering and Regenerative Medicine, 15 (3). pp. 249-261.

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Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent�s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI. © 2018, The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V., part of Springer Nature.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Cytology; Disease control; Magnetic resonance imaging; Medical applications; Molecular imaging; Nanoparticles; Regenerative Medicine; Superparamagnetism, Cell therapy; Multiple sclerosis; Non-invasive imaging; Stem cell transplantation; Superparamagnetic nanoparticles; Superparamagnetics; Transplanted cells; Urinary system disease, Stem cells, fluorine; gadolinium chelate; iron nanoparticle; nuclear magnetic resonance imaging agent; superparamagnetic iron oxide nanoparticle; ultrasmall superparamagnetic iron oxide, cardiovascular system; cell tracking; cerebrovascular accident; human; injury; joint; mesenchymal stem cell; molecular imaging; nervous system; nonhuman; nuclear magnetic resonance imaging; pancreas; positron emission tomography; priority journal; regenerative medicine; reporter gene; Review; single photon emission computed tomography; stem cell; stem cell transplantation; urinary tract
Subjects: QU Biochemistry. Cell Biology and Genetics
Depositing User: eprints admin
Date Deposited: 23 Dec 2018 06:01
Last Modified: 23 Dec 2018 06:01

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