More Protection of Lactobacillus acidophilus Than Bifidobacterium bifidum Probiotics on Azoxymethane-Induced Mouse Colon Cancer

Agah, S. and Alizadeh, A.M. and Mosavi, M. and Ranji, P. and Khavari-Daneshvar, H. and Ghasemian, F. and Bahmani, S. and Tavassoli, A. (2018) More Protection of Lactobacillus acidophilus Than Bifidobacterium bifidum Probiotics on Azoxymethane-Induced Mouse Colon Cancer. Probiotics and Antimicrobial Proteins. pp. 1-8.

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Abstract

Based on the ability of the probiotics in the gut microflora modification, they can have the beneficial effects on diseases in the short and/or the long term. In previous study, we revealed that unlike Bifidobacterium bifidum, the amount of Lactobacillus acidophilus remained almost unchanged in mice gut microflora in the long term, indicating more stability of L. acidophilus than B. bifidum which can be used to prevent some incurable diseases such as cancer. Thirty-eight male BALB/c mice were divided into four groups, control, azoxymethane (AOM), L. acidophilus, and B. bifidum probiotics, to evaluate the protective effects of the probiotics on AOM-induced mouse colon cancer. Except for the control group, the rest of the animals were weekly given AOM (15 mg/kg, s.c) in three consecutive weeks. Colon lesion incidence was 74 in the AOM group in comparison with the control (0) (P < 0.05). The lesions were varied from mild to severe dysplasia and colonic adenocarcinoma. Administration of the probiotics inhibited the incidence of colonic lesions by about 57 in L. acidophilus (P < 0.05) and 27 in B. bifidum (P > 0.05) compared to the AOM group. The serum levels of CEA and CA19-9 tumor markers were significantly decreased in L. acidophilus in comparison with the AOM group (P < 0.05). Moreover, the serum levels of IFN-γ and IL-10 and the number of CD4+ and CD8+ cells were significantly increased in L. acidophilus compared to AOM (P < 0.05). Our study highlighted the more potential effects of L. acidophilus probiotic than B. bifidum on mouse colon cancer. © 2018 Springer Science+Business Media, LLC, part of Springer Nature

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: WI Digestive System
Depositing User: eprints admin
Date Deposited: 19 Dec 2018 12:56
Last Modified: 17 Aug 2019 06:52
URI: http://eprints.iums.ac.ir/id/eprint/6682

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