Management and outcomes of treating pediatric medulloblastoma: an eight years� experience in an Iranian pediatric center

Mehrvar, A. and Tashvighi, M. and Hedayati Asl, A.A. and Niktoreh-Mofrad, N. and Mehrvar, N. and Afsar, N. and Naderi, A. and Allebouyeh, M. and Qaddoumi, I. and Faranoush, M. (2018) Management and outcomes of treating pediatric medulloblastoma: an eight years� experience in an Iranian pediatric center. Child's Nervous System, 34 (4). pp. 639-647.

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Purpose: The clinical management of pediatric medulloblastoma requires a multidisciplinary approach, which can be challenging, especially in low- and middle-income countries. The aim of this study was to identify current challenges and describe the treatment and outcomes of Iranian pediatric patients with medulloblastoma who were referred to our center in Tehran, Iran. Methods: Our retrospective review included 126 patient records from April 2007 to May 2015. The records were analyzed for epidemiologic features, treatment modalities, overall survival, and progression-free survival. Data were analyzed using SPSS 22.0 software. Results: Median age at diagnosis was 6 years (male:female ratio, 2.3:1). At the time of diagnosis, 7 patients were 2 years or younger, and 76 (60.3) were categorized as having high-risk disease. Overall, 100 patients had gross or near-total surgical resection. Cerebral spinal fluid involvement was detected in 22.2 of the patients tested, and spinal involvement was detected in 25 of the patients who underwent spinal MRI. Metastasis stages at the time of diagnosis were as follows: M0: 48.4 patients, M1: 16.7, M2: 5.5, and M3: 21.4. Median times of follow-up and progression-free survival were 16 and 12 months, respectively. Probability of 7-year overall survival and progression-free survival were 59 and 53.8, respectively. Conclusions: Results of the current retrospective study emphasize the need for implementing measures to improve outcome for our patients with medulloblastoma. Such measures include a multidisciplinary approach, unified national treatment guidelines, better disease and metastasis staging, twinning initiatives, and seeking a second opinion when needed. © 2017, Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: lomustine; prednisolone; vincristine, acute myeloid leukemia; Article; brain ventricle peritoneum shunt; cancer chemotherapy; cancer radiotherapy; cancer recurrence; cancer staging; cancer surgery; cerebrospinal fluid; cerebrospinal fluid cytology; child; childhood cancer; clinical outcome; female; follow up; hearing impairment; high risk population; human; Iran; Iranian (citizen); major clinical study; male; medulloblastoma; metastasis; multiple cycle treatment; neuroimaging; nuclear magnetic resonance imaging; overall survival; pediatric hospital; post treatment survival; priority journal; progression free survival; retrospective study; second look surgery; spine; ventriculostomy
Subjects: WS Pediatrics
Depositing User: eprints admin
Date Deposited: 17 Dec 2018 09:32
Last Modified: 17 Aug 2019 05:19

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