Plasticity after pediatric cochlear implantation: Implication from changes in peripheral plasma level of BDNF and auditory nerve responses

Alemi, R. and Motassadi Zarandy, M. and Joghataei, M.T. and Eftekharian, A. and Zarrindast, M.R. and Vousooghi, N. (2018) Plasticity after pediatric cochlear implantation: Implication from changes in peripheral plasma level of BDNF and auditory nerve responses. International Journal of Pediatric Otorhinolaryngology, 105. pp. 103-110.

Full text not available from this repository.
Official URL:


Introduction Sensory neural hearing loss could lead to some structural and physiological changes in the auditory pathways, such as alteration in the expression of neurotrophins. These factors, especially Brain-Derived Neurotrophic Factor (BDNF), play an important role in synaptic functions and experience-related plasticity. Restoring cochlear function after hearing loss is possible through cochlear implantation (CI). Evaluation of the blood concentration changes of neurotrophins as prerequisites of plasticity could help scientists to determine the prognosis of CI as in the candidacy procedure or enhancing prosthesis function by adding the exact needed amount of BDNF to the electrode array. Methods Here we have studied the plasma BDNF concentration before CI surgery and 6 months after using CI device in 15 pediatric CI recipients and compared this level with changes of BDNF concentration in 10 children who were using hearing aid (H.A). In addition, we searched for a possible correlation between post-surgery plasma BDNF concentration and electrical compound action potential (ECAP) and comfort-level (C-level) thresholds. Results Plasma BDNF concentration in children with CI increased significantly after CI surgery, while this difference in H.A group was not significant. Analysis of repeated measures of ECAP and C-level thresholds in CI group showed that there were some kinds of steadiness during follow- up sessions for ECAP thresholds in basal and E16 of middle electrodes, whereas C-level thresholds for all selected electrodes increased significantly up to six months follow-up. Interestingly, we did not find any significant correlation between post-surgery plasma BDNF concentration and ECAP or C-level threshold changes. Conclusion It is concluded that changes in C-level threshold and steady state of ECAP thresholds and significant changes in BDNF concentration could be regarded as an indicator of experienced-related plasticity after CI stimulation. © 2017 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: brain derived neurotrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor, human, action potential; Article; blood sampling; child; clinical article; cochlear implantation; cochlear nerve; controlled study; enzyme linked immunosorbent assay; female; follow up; human; male; nerve cell plasticity; pediatrics; perception deafness; priority journal; protein blood level; auditory threshold; blood; cochlea prosthesis; cochlear implantation; cochlear nerve; hearing aid; nerve cell plasticity; pathophysiology; physiology; preschool child; procedures, Action Potentials; Auditory Threshold; Brain-Derived Neurotrophic Factor; Child; Child, Preschool; Cochlear Implantation; Cochlear Implants; Cochlear Nerve; Enzyme-Linked Immunosorbent Assay; Female; Hearing Aids; Hearing Loss, Sensorineural; Humans; Male; Neuronal Plasticity
Subjects: WV Otolaryngology
Depositing User: eprints admin
Date Deposited: 11 Dec 2018 15:09
Last Modified: 14 Aug 2019 09:27

Actions (login required)

View Item View Item