The potential roles of bacteria to improve radiation treatment outcome

Kouhsari, E. and Ghadimi-Daresajini, A. and Abdollahi, H. and Amirmozafari, N. and Mahdavi, S.R. and Abbasian, S. and Mousavi, S.H. and Yaseri, H.F. and Moghaderi, M. (2018) The potential roles of bacteria to improve radiation treatment outcome. Clinical and Translational Oncology, 20 (2). pp. 127-139.

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Many combined therapies have been proposed to enhance radiotherapy outcome, but they have several limitations. As a new feasible strategy, combination of radiotherapy with bacteria showed a significant positive impact on the tumor treatment and metastasis inhibition. Although probiotic bacteria and radiotherapy alone can be effective in the treatment of different cancers, the combination of these two therapies seems to enhance therapeutic outcome and is cost-effective. Bacterial cells can act as therapeutic/gene/drug delivery vehicles as well as theranostic agents. In this communication, we reviewed current evidences, studies, suggestions, and future-based directions on combination of radiotherapy and bacteria. In another sections, an overview on tumor hypoxia, bacteria in cancer therapy, and combination of radiotherapy and bacteria is presented. A brief overview on trials and animal studies which used bacteria to protect normal tissues against radiotherapy-induced complications is also included. © 2017, Federación de Sociedades Españolas de Oncología (FESEO).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: radioprotective agent; radiosensitizing agent; probiotic agent, antineoplastic activity; bacterial cell; bacterium; cancer radiotherapy; carcinogenesis; drug delivery system; gene delivery system; immune response; immunomodulation; ionizing radiation; metastasis inhibition; nonhuman; Review; theranostic nanomedicine; treatment outcome; tumor hypoxia; bacterium; drug delivery system; growth, development and aging; human; multimodality cancer therapy; neoplasm; radiotherapy; treatment outcome, Bacteria; Combined Modality Therapy; Drug Delivery Systems; Humans; Neoplasms; Probiotics; Radiotherapy; Treatment Outcome
Subjects: WN Radiology. Diagnostic Imaging
Depositing User: eprints admin
Date Deposited: 11 Dec 2018 14:08
Last Modified: 14 Aug 2019 08:49

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