Early insulin glargine initiation in iranian people with uncontrolled type 2 diabetes: Glycemic control, and adverse events

Khamseh, M.E. and Esteghamati, A. and Niafar, M. and Abbasi, D. and Beiki, M.M. (2018) Early insulin glargine initiation in iranian people with uncontrolled type 2 diabetes: Glycemic control, and adverse events. Acta Medica Iranica, 56 (4). pp. 249-254.

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Abstract

To explore glycemic control, and adverse events of Iranian people with uncontrolled type 2 diabetes after initiation of long-acting basal insulin, glargine. People with uncontrolled type 2 diabetes that was on at least two oral anti-diabetic drugs (OAD) were enrolled in this observational prospective study. Insulin glargine was prescribed by physicians in the course of routine clinical practice. Patients were followed for 24 weeks. Insulin doses were titrated to reach fasting blood sugar (FBS) target between 90 mg/dl and 130 mg/dl. HbA1c and adverse events were recorded at baseline, week 12, and week 24. Form a total of 292 participants, 243 patients completed the study. HbA1c, FBS, postprandial glucose, total cholesterol, triglycerides, and low-density lipoprotein cholesterol, but not body mass index decreased during the study. The proportion of poorly controlled patients (HbA1C>9) decreased from 172 (58.9) to 39(13.4), and 21(7.2) during follow up. Controlled glycemia (HbA1C<7) was detected in 7(2.4), 48 (16.4) and 56 (19.2) of patients at baseline, week 12 and week 24. Hypoglycemia was reported in 5.1 and 3.4 of the participants in the week at 12 and 24, respectively. Patients felt more satisfied with their blood glucose control, timing and choices of meals, and hypo/hyperglycemic experiences. Insulin glargine initiation in people with uncontrolled type 2 diabetes on 2 OADs is associated with significant improvement in metabolic control. Insulin glargine has good safety profile and well tolerated by the patients. © 2018 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: glucose; hemoglobin A1c; insulin glargine; low density lipoprotein cholesterol; oral antidiabetic agent; triacylglycerol, adult; Article; blood glucose monitoring; body mass; cholesterol blood level; clinical practice; female; glucose blood level; glycemic control; human; hypoglycemia; insulin treatment; Iranian people; major clinical study; male; metabolic regulation; middle aged; non insulin dependent diabetes mellitus; observational study; prospective study; tremor; weakness
Subjects: WK Endocrine System
Depositing User: eprints admin
Date Deposited: 10 Dec 2018 09:32
Last Modified: 30 Jul 2019 06:00
URI: http://eprints.iums.ac.ir/id/eprint/7098

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