Comparison effect of pre-emptive gabapentin and oxycodone on pain after abdominal hysterectomy: A double blind randomized clinical trial

Hassani, V. and Zaman, B. and Alimian, M. and Safaeian, R. and Mehdizadehkashi, A. and Karami, S. and Ommi, D. (2018) Comparison effect of pre-emptive gabapentin and oxycodone on pain after abdominal hysterectomy: A double blind randomized clinical trial. Acta Medica Iranica, 56 (4). pp. 244-248.

[img]
Preview
 Text
Comparison effect of pre-emptive gabapentin and oxycodone on pain after abdominal hysterectomy A double blind randomized clinical trial.pdf
Download (441kB) | Preview
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Gabapentin is popular analgesic adjuvants for improving postoperative pain management. The aim of this study was to compare the preventive effects of pre-emptive oxycodone and gabapentin on acute pain after elective abdominal hysterectomy. One hundred patients undergoing abdominal hysterectomy were randomly assigned to oxycodone group received 10 mg of oxycodone and gabapentin group received 10 mg of gabapentin 1 hour before surgery. The anesthetic technique was standardized, and the postoperative assessments included the amount of meperidine consumption, PONV and VAS for postoperative pain at arrival to recovery, 6, 12 and 24 h after surgery. Bleeding loss assessed during surgery. Postoperative pain scores were significantly lower in the gabapentin group compared with the oxycodone group. (P=0.0001) The total meperidine used in the gabapentin group was significantly less than in the oxycodone group. Postoperative nausea and vomiting (PONV) and blood loss during surgery were significantly decreased in gabapentin group. Based on the results of this study, Pre-emptive use of gabapentin 1200 mg orally, significantly decreases postoperative pain and PONV, rescues analgesic requirements and also bleeding loss during surgery in patients who undergo abdominal hysterectomy. Significant side effects were not observed. © 2018 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: WP Gynecology
Depositing User: eprints admin
Date Deposited: 28 Nov 2018 15:25
Last Modified: 27 Aug 2019 06:34
URI: http://eprints.iums.ac.ir/id/eprint/7192

Actions (login required)

View Item View Item
Iran University of Medical Sciences Scientific Repository is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.