Effect of supplementation with a combination of l-arginine, l-glutamine, and hydroxy methyl butyrate on cachexia: A systematic review

Asghari Hanjani, N. and Farsi, F. and Sepidarkish, M. and Omidi, A. and Ardehali, S.H. and Akbari-Fakhrabadi, M. and Heshmati, J. (2018) Effect of supplementation with a combination of l-arginine, l-glutamine, and hydroxy methyl butyrate on cachexia: A systematic review. Journal of Food Biochemistry.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....


Weight loss in the form of cachexia is a comorbid condition which is associated with delayed recovery, especially in cancer and human immunodeficiency virus (HIV)-infected patients. Arginine (Arg), Glutamine (Gln), and the Leucine metabolite, Hydroxy methyl butyrate (HMB) are substrates which have been investigated due to their potential role in ameliorating muscle mass. We conducted a systematic review to appraise available studies assessing the effect of Arg, Gln, and HMB supplementation on improving body weight and muscle mass in those with pathological conditions. A comprehensive search for studies published between January 1990 and November 2017 was performed. The interested primary outcome of this systematic review was weight. Two reviewers independently searched databases and 125 papers were identified from the initial search, overall, we selected five studies that were suitable for our systematic review. The results of the studies shows that this combination can improve fat free mass, weight and immune function in cachexia and morbid weight loss patients. Practical Applications. Cachexia is one of the main problems in many chronic diseases. Providing a nutritional support is usually the main concern in patients with severe weight loss due to the impaired appetite and gastrointestinal tract irritation. Among nutrition interventions, Protein and amino acid supplementation receive much attention due to the loss of muscle tissue and the negative balance of protein and nitrogen in patients with severe weight loss. Arg, Gln, and HMB (Arg/Gln/HMB) supplementation can improve weight gain and prevent weight loss in chronic diseases. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0; Article in Press
Uncontrolled Keywords: Amino acids; Arginine; Muscle; Nutrition; Patient rehabilitation; Patient treatment; Proteins; Viruses, Amino acid supplementation; cachexia; cancer; Gastrointestinal tract; glutamine; Human immunodeficiency virus; Pathological conditions; Weight loss, Diseases
Subjects: WE Musculoskeletal System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 28 Nov 2018 14:21
Last Modified: 28 Nov 2018 14:21
URI: http://eprints.iums.ac.ir/id/eprint/7209

Actions (login required)

View Item View Item