Ahmadikia, K. and Kordbacheh, P. and Shadpour, P. and Nami, S. and Sarrafnejad, A. and Mahmoodi, M. and Safara, M. and Rokni, M. and Yarahmadi, M. and Mahmoudi, S. and Khezri, M. and Zaini, F. (2018) Increased urine Interleukin-17 and Interleukin-22 levels in patients with candidal urinary tract infection. Iranian Journal of Kidney Diseases, 12 (1). pp. 33-39.
Full text not available from this repository.Abstract
Introduction. Candiduria is common in the hospitalized patients. This study aimed to quantify interleukin (IL)-17 and IL-22 levels in urine of candiduric patients. Materials and Methods. A case-control study was conducted on inpatients at Hashemi Nejad Kidney Center. Thirty-four patients were identified with Candida species in their urine samples (> 103 colony-forming units per milliliter and presence of Candida species only). Urine samples with concomitant infections were excluded. Thirty-four patients with negative direct examination and culture were included as the control patients. Interleulin-17 and IL-22 levels were measured in the lyophilized and nonlyophilized urine. The relevant cytokine titers of the two groups were compared, and the association of cytokine elevation and candiduria was investigated. Results. The majority of the candiduric patients were from the intensive care and urology units of women. Only 4 patients (11.7) manifested fever and dysuria. Massive leukocyturia was observed in 4 patients. Candida glabrata was the most commonly isolated species (44). Levels of the urine IL-17 and IL-22 were significantly elevated in the candiduric patients, when compared to the noncandiduric controls. While an increased IL-17 level was significantly associated with candiduria (odds ratio, 1.09; 95 confidence interval, 1.003 to 1.17; P = .04), an increased IL-22 level was not. The results showed that lyophilized urine samples maximized the detection power of urinary cytokines. Conclusions. Our results indicated that direct examination, fungal urine culture, and investigation of urine IL-17 and IL-22 levels are useful tools for diagnosis of Candida urinary tract infection. © 2018, Iranian Society of Nephrology. All rights reserved.
| Item Type: | Article |
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| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | antibiotic agent; interleukin 17; interleukin 22; biological marker; interleukin 17; interleukin derivative; interleukin-22, adult; Article; Candida; Candida albicans; Candida glabrata; Candida tropicalis; candiduria; case control study; clinical article; colony forming unit; controlled study; diagnostic test accuracy study; dysuria; enzyme linked immunosorbent assay; erythrocyte sedimentation rate; female; fever; freeze drying; human; inflammation; leukocyturia; limit of detection; male; middle aged; Pichia kudriavzevii; pyuria; receiver operating characteristic; sensitivity and specificity; urinalysis; urinary tract infection; adolescent; aged; bacterial count; Candida; candidiasis; chi square distribution; classification; isolation and purification; microbiology; multivariate analysis; odds ratio; statistical model; upregulation; urinary tract infection; urine; very elderly; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Candida; Candidiasis; Case-Control Studies; Chi-Square Distribution; Colony Count, Microbial; Female; Humans; Interleukin-17; Interleukins; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Up-Regulation; Urinalysis; Urinary Tract Infections; Young Adult |
| Subjects: | WJ Urogenital System |
| Depositing User: | eprints admin |
| Date Deposited: | 27 Nov 2018 13:23 |
| Last Modified: | 27 Nov 2018 13:23 |
| URI: | http://eprints.iums.ac.ir/id/eprint/7247 |
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