Epidemiology of culture-negative peritonitis in iranian patients on continuous ambulatory peritoneal dialysis

Najafi, I. and Ossareh, S. and Hosseini, M. and Ganji, M.R. and Naghibi, M. and Makhdoomi, K. and Ardalan, M.R. and Nouri-Majalan, N. and Azmandian, J. and Sanadgol, H. and Seirafian, S. and Atabak, S. (2011) Epidemiology of culture-negative peritonitis in iranian patients on continuous ambulatory peritoneal dialysis. Iranian Journal of Kidney Diseases, 5 (5). pp. 332-337.

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Introduction. Culture-negative peritonitis is a major challenge in the treatment of peritonitis in continuous ambulatory peritoneal dialysis (CAPD). This study aimed to evaluate the culture-negative peritonitis in patients from the Iranian CAPD Registry. Materials and Methods. Data of 1472 patients from 26 CAPD centers were analysed. Peritonitis was defined as any clinical suspicion together with peritoneal leukocyte count of 100/mL and more. Results. The patients had been on PD for a mean of 500 ± 402 days. There were a total of 660 episodes of peritonitis observed among 299 patients (peritonitis rate of 1 episode in 34.1 patient-months). Excluding patients with both negative and positive culture results, there were 391 episodes of peritonitis in 220 patients (174 culturepositive episodes in 97 patients and 217 culture-negative episodes in 123). The 1- to 4-year patient survival rates were 85, 75, 69, and 59 for the patients with culture-positive peritonitis, and 92, 78, 73 and 63 for the patients with culture-negative peritonitis, respectively (P =.34). The technique survival rates were 90, 57, 42, and 27 and 95, 85, 74, and 40, respectively (P =.001). On follow-up, there were higher rates of active PD patients, lower rates of PD dropouts, and higher rates of kidney transplantation in patients with culture-negative peritonitis compared to those with culture-positive peritonitis. Conclusions. In our patients, the prevalence of culture-negative peritonitis was high (55.9). Patient survival with culture-negative peritonitis was comparable to those with culture-positive peritonitis and technique survival was higher among those with culturenegative peritonitis.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: adult; article; bacterium culture; clinical evaluation; clinical feature; continuous ambulatory peritoneal dialysis; controlled study; culture technique; disease registry; female; follow up; fungus culture; human; infection risk; kidney failure; kidney transplantation; leukocyte count; major clinical study; male; peritonitis; prevalence; risk assessment; risk factor; survival rate; treatment duration, Female; Humans; Iran; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Peritonitis
Subjects: WI Digestive System
QU Biochemistry. Cell Biology and Genetics
Depositing User: somayeh pourmorteza
Date Deposited: 05 Jan 2019 10:03
Last Modified: 05 Jan 2019 10:03
URI: http://eprints.iums.ac.ir/id/eprint/7365

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