Predicting age at menopause from serum antimüllerian hormone concentration

Tehrani, F.R. and Shakeri, N. and Solaymani-Dodaran, M. and Azizi, F. (2011) Predicting age at menopause from serum antimüllerian hormone concentration. Menopause, 18 (7). pp. 766-770.

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Objective: We aimed to estimate age at menopause using serum antimüllerian hormone (AMH) concentration. Methods: We randomly selected 266 study participants from a pool of 1,265 eligible women in the Tehran Lipid and Glucose Study cohort. We measured AMH levels three times at about 3-year intervals. There were 63 occurrences of menopause in our participants over an average of 6-year follow-up. We built an accelerated failure time model using serum AMH level at the start of follow-up to estimate age at menopause. The goodness of fit for the model was tested using Cox-Snell residuals and the Bland-Altman plot. Results: We estimated ages at menopause for different levels of serum AMH concentration among women aged 20 to 49 years. For those who reached menopause, serum AMH concentrations about 6 years before the event provided fairly accurate estimates of the age at menopause. The Bland-Altman plot showed an acceptable agreement between predicted and observed values. Conclusions: Serum AMH concentrations can reasonably forecast the age at menopause for individual women. © 2011 by The North American Menopause Society.

Item Type: Article
Additional Information: cited By 62
Uncontrolled Keywords: Muellerian inhibiting factor, adult; age determination; article; female; follow up; hormone blood level; human; menopause, Adult; Age Distribution; Anti-Mullerian Hormone; Biological Markers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Menopause; Middle Aged; Predictive Value of Tests; Time Factors
Subjects: WQ Obstetrics
Depositing User: somayeh pourmorteza
Date Deposited: 05 Jan 2019 10:45
Last Modified: 05 Jan 2019 10:45

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