Protective effects of tocopherol on ABR threshold shift in rabbits exposed to noise and carbon monoxide

Kashani, M.M. and Mortazavi, S.B. and Khavanin, A. and Allameh, A. and Mirzaee, R. and Akbari, M. (2011) Protective effects of tocopherol on ABR threshold shift in rabbits exposed to noise and carbon monoxide. Iranian Journal of Pharmaceutical Research, 10 (2). pp. 339-346.

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Noise induced hearing loss (NIHL) is one of the most important occupational disease worldwide. NIHL has been found potentiate by simultaneous carbon monoxide (CO) exposure. Free radicals have been implicated in cochlear damage resulted from the exposure to noise and due to the CO hypoxia. This study examined whether α-tocopherol administration, as a free radical scavenger, causes the attenuation of auditory brainstem response (ABR) threshold shifts resulting from noise exposure and noise plus CO exposure. Forty-two rabbits were divided into seven groups including control, noise + saline, noise + CO + saline, noise + α-tocopherol, noise + CO + α-tocopherol, CO + α-tocopherol and α-tocopherol alone. ABR was assessed before exposure, 1 h and 14 days post exposure. The administration of 50 mg/Kg of α-tocopherol prior, following and post exposure to noise or noise plus CO recovered permanent ABR threshold shift at 1 and 2 KHz almost to the baseline and provided significant attenuation in permanent ABR threshold shift at 4 and 8 KHz in subjects which were exposed to noise but it did not block the potentiating of threshold elevation by CO exposure (extra threshold loss by combined exposure) at 4 and 8 KHz. α-Tocopherol provides protective effect against the hearing loss resulting from noise exposure and simultaneous exposure to noise plus CO. © 2011 by School of PharmacyShaheed Beheshti University of Medical Sciences and Health Services.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: alpha tocopherol; carboxyhemoglobin, adult; animal experiment; antioxidant activity; Article; auditory threshold; biochemical analysis; carbon monoxide intoxication; controlled study; evoked brain stem auditory response; hearing impairment; male; noise injury; nonhuman; rabbit
Subjects: WA Public Health
Depositing User: somayeh pourmorteza
Date Deposited: 06 Jan 2019 08:06
Last Modified: 06 Jan 2019 08:06

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