Anti-hyperglycemic effect of aqueous extract of Juglans regia L. leaf (walnut leaf) on type 2 diabetic patients: A randomized controlled trial

Abdoli, M. and Dabaghian, F.H. and Goushegir, A. and Shirazi, M.T. and Nakhjavani, M. and Shojaii, A. and Rezvani, S. and Mahlooji, K. (2017) Anti-hyperglycemic effect of aqueous extract of Juglans regia L. leaf (walnut leaf) on type 2 diabetic patients: A randomized controlled trial. Advances in Integrative Medicine, 4 (3). pp. 98-102.

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Objective: The Juglans regia leaf (walnut leaf) has been traditionally used to treat diabetes in Iran. The aim of this study was to evaluate the effect of aqueous extract of Juglans regia leaf on blood glucose in type 2 diabetic patients. Methods: Thirty-seven type 2 diabetic patients aged 35�70 years with fasting blood glucose levels between 130 mg/dl (7.2 mmol/L) and 250 mg/dl (13.9 mmol/L) and HbA1c more than 7 despite using conventional oral hypoglycemic drugs received the Juglans regia capsule (250 mg/TDS) or toast powder capsule (placebo) randomly for 3 months. Fasting blood glucose (FPG), postprandial blood glucose (PPG), and glycosylated hemoglobin (HbA1c) were assessed as primary outcome measures. Lipid profile and hepatic and renal function were assessed as secondary outcome measures. Nonparametric statistical tests were employed to compare the results with baseline in both groups using SPSS version 17. Results: Nineteen patients in the Juglans regia group and 18 in the control group with a mean (±SD) age 55.8 (±7) completed the study. The FPG (p = 0.02), PPG (p = 0.008) and HbA1c (p = 0.003) levels decreased significantly in the Juglans regia group after 3 months compared to baseline without any side effects. The changes of the variables were not significant in the control group. Conclusions: This study suggests that the aqueous extract of J. regia leaf had a lowering effect of FPG, PPG and HbA1c in type 2 diabetic patients. Conducting further clinical studies is suggested with larger sample sizes to make precise conclusions about the efficacy and safety of this herb. © 2017 Elsevier Ltd

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: alanine aminotransferase; antidiabetic agent; aspartate aminotransferase; creatinine; flavonoid; hemoglobin A1c; Juglans regia extract; plant extract; unclassified drug, adult; aged; antidiabetic activity; Article; clinical article; controlled study; double blind procedure; female; glucose blood level; high performance liquid chromatography; human; Juglans regia; kidney function; liver function; male; non insulin dependent diabetes mellitus; plant leaf; priority journal; randomized controlled trial; treatment outcome; urea nitrogen blood level
Subjects: WZ History of Medicine. Medical Miscellany
WK Endocrine System
Depositing User: eprints admin
Date Deposited: 01 Jan 2019 12:22
Last Modified: 01 Jan 2019 12:22

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