Abbasi-Maleki, S. and Bakhtiarian, A. and Nikoui, V. (2017) Involvement of the monoaminergic system in the antidepressant-like effect of the crude extract of Mentha piperita (Lamiaceae) in the forced swimming test in mice. Synergy, 5. pp. 21-28.
Full text not available from this repository.Abstract
The aim of the present study was to investigate the involvement of the monoaminergic system in antidepressant-like effects of a characterized ethanolic extract of Mentha piperita (MP) in the forced swimming test (FST) in male mice. The animals were intraperitoneally (i.p.) treated with the MP extract (50�400 mg/kg) one hour before FST. To examine the involvement of the monoaminergic system in the antidepressant-like effect of MP, receptor antagonists were administrated fifteen minutes prior to the MP extract treatment (400 mg/kg, i.p) to mice and after one hour the FST was carried out. The MP extract (200 and 400 mg/kg, i.p.) showed a significant antidepressant-like effect (P < 0.001), in the FST, but it did not change the spontaneous locomotor activities in the open-field test. Pretreatment of animals with SCH23390, sulpiride, haloperidol, prazosin, yohimbine, WAY100135, ketanserin, and p-chlorophenylalanine (pCPA) reversed the antidepressant-like effect of the MP extract (400 mg/kg, i.p.) in the FST. In addition, the administration of reserpine increased the duration of immobility elicited by the MP extract in animals. Combinations of the MP extract (50 mg/kg, i.p.,) with sub-effective doses of fluoxetine (5 mg/kg, i.p.) or imipramine (5 mg/kg, i.p.) potentiated the antidepressant-like response. The ethanolic extract of MP exerts antidepressant-like effects, which might be mediated through dopaminergic (D1 and D2), noradrenergic (α1 and α2), and serotonergic (5-HT1A, 5-HT2A) receptors. These first results including the potentiating effect of the MP extract on fluoxetine and imipramine suggest further investigations of MP for the management of depression. © 2017 Elsevier GmbH
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 2 |
| Uncontrolled Keywords: | fenclonine; fluoxetine; haloperidol; imipramine; ketanserin; n 2 4 (2 methoxyphenyl) 1 piperazinyl]ethyl] n (2 pyridyl)cyclohexanecarboxamide; peppermint; prazosin; reserpine; sch23390; sulpiride; yohimbine, animal experiment; animal model; antidepressant activity; Article; controlled study; depression; dopaminergic system; drug mechanism; forced swim test; hyperactivity; immobility; male; Mentha piperita; monoaminergic system; mouse; nonhuman; noradrenergic system; open field test; priority journal; rearing; serotoninergic system; tachycardia |
| Subjects: | WM Psychiatry |
| Depositing User: | eprints admin |
| Date Deposited: | 30 Dec 2018 09:58 |
| Last Modified: | 30 Dec 2018 09:58 |
| URI: | http://eprints.iums.ac.ir/id/eprint/7632 |
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