The impact of KIR�HLA genotype on hepatitis B virus clearance in Iranian infected individuals

Shah-Hosseini, A. and Jafari, M. and Mohammadi, A. and Sanaei, R. and Alavian, S.M. and Doosti-Irani, A. and Nooradeh Keykavousi, M. and Tajik, N. (2017) The impact of KIR�HLA genotype on hepatitis B virus clearance in Iranian infected individuals. Medical Microbiology and Immunology, 206 (6). pp. 463-470.

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Killer cell immunoglobulin like receptors (KIRs) have a principal role in regulating the effector functions of NK cells, particularly in viral infections. The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules. The aim of this study is to investigate the possible association of KIR genes, their known HLA ligands and compound KIR�HLA genotypes with hepatitis B virus (HBV) infection. Our study group consisted of 202 Iranian HBV-infected patients (52 spontaneously recovered, 50 asymptomatic carriers, 50 chronic sufferers and 50with liver cirrhosis) and 100 ethnic-matched healthy control subjects. KIR and HLA genotyping was performed by a polymerase chain reaction�sequence-specific primer (PCR�SSP). The frequencies of the KIR2DL5A, KIR2DS1, and KIR3DS1 genes were significantly elevated in recovered individuals when compared with both control and patient groups. Also, KIR2DL5, and KIR3DP1 full were escalated in recovered individuals in comparison with patient groups. In addition, HLA-Bw4 ligand and HLA-A Bw4 were highly frequent in recovered individuals compared with healthy controls. Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4Iso80, and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups. Interestingly, AA genotype had less frequency and Bx had higher frequency in recovered individuals compared with both healthy control and patient groups. Our findings suggest a potential impact of the NK cells� activating phenotype that leads to the HBV clearance in infected individuals. © 2017, Springer-Verlag GmbH Germany.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: adult; Article; chronic hepatitis B; clinical article; controlled study; gene frequency; gene sequence; genetic association; genotype; Hepatitis B virus; HLAABw4 gene; human; Iranian people; KIR2DL5 gene; KIR2DL5A gene; KIR2DS1 gene; KIR3DP1 gene; KIR3DS1 gene; liver cirrhosis; nonhuman; polymerase chain reaction; priority journal; viral clearance; virus gene; virus pathogenesis; female; genetic predisposition; genetics; genotype; genotyping technique; hepatitis B; Iran; male; middle aged; young adult, killer cell immunoglobulin like receptor; La protein, human; phosphoprotein, Adult; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; Hepatitis B; Humans; Iran; Male; Middle Aged; Phosphoproteins; Polymerase Chain Reaction; Receptors, KIR; Young Adult
Subjects: WH Hemic and Lymphatic Systems
Depositing User: eprints admin
Date Deposited: 26 Dec 2018 12:39
Last Modified: 21 Aug 2019 06:01

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