Shafiee, G. and Kelishadi, R. and Heshmat, R. and Qorbani, M. and Motlagh, M.E. and Aminaee, T. and Ardalan, G. and Taslimi, M. and Poursafa, P. and Larijani, B. (2013) First report on the validity of a continuous Metabolic Syndrome score as an indicator for Metabolic Syndrome in a national sample of paediatric population - The CASPIAN-III study. Endokrynologia Polska, 64 (4). pp. 278-284.
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Abstract
Introduction: The aim of this study was to assess the validity of a continuous Metabolic Syndrome score (cMetS) in a nationally representative sample of Iranian children and to identify sex and age-specific optimal cut-off points of cMetS that are associated with MetS. Material and methods: This study was conducted among 3,254 schoolchildren aged 10-18 years. cMetS was derived by aggregating age and sex-standardised residuals of waist circumference (WC), mean arterial pressure (MAP), glucose, high density lipoprotein-cholesterol (HDL-C) and triglycerides (TG). To determine the optimal cut-off points of cMetS for predicting MetS, receiver operator characteristic (ROC) curve analysis was used with an estimation of the variables' sensitivity and specificity. Results: A graded relationship was documented between cMetS and the number of risk factors. Increasing mean values of cMetS with increasing numbers of components were apparent for both genders. The overall optimal cMetS cut-off point for predicting the presence of MetS was 2.93 sensitivity = 92%, specificity = 91%, area of the curve = 0.96 (0.95-0.97). The values for boys and girls were 2.97 and 3.26 respectively in the total study. Conclusion: This nationwide study confirmed the validity of the cMetS score in a population-based sample of Iranian children. cMetS appears to be an appropriate index for investigating the association between potential risk factors and MetS in epidemiological research in Iran.
| Item Type: | Article |
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| Additional Information: | cited By 11 |
| Uncontrolled Keywords: | glucose; high density lipoprotein cholesterol; triacylglycerol; biological marker; cholesterol; triacylglycerol, adolescent; article; child; continuous metabolic syndrome score; female; gender; human; Iran; major clinical study; male; mean arterial pressure; metabolic syndrome X; risk factor; school child; scoring system; sensitivity and specificity; validity; waist circumference; blood; body mass; complication; epidemiology; health status; metabolic syndrome X; Pediatric Obesity; predictive value; procedures; receiver operating characteristic; risk assessment; validation study, Adolescent; Biological Markers; Body Mass Index; Child; Cholesterol; Female; Health Status; Humans; Iran; Male; Metabolic Syndrome X; Pediatric Obesity; Predictive Value of Tests; Risk Assessment; ROC Curve; Sensitivity and Specificity; Triglycerides; Waist Circumference |
| Subjects: | WK Endocrine System |
| Depositing User: | somayeh pourmorteza |
| Date Deposited: | 01 Jun 2019 05:09 |
| Last Modified: | 01 Jun 2019 05:09 |
| URI: | http://eprints.iums.ac.ir/id/eprint/9582 |
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