Impact of metoclopramide on image quality in myocardial perfusion imaging

Yaghoobi, N. and Mardanshahi, A. and Rastgou, F. and Malek, H. and Firouzabady, S.-H. and Rajabi, A.B. and Amouzadeh, H. and Vaseghi, S. (2012) Impact of metoclopramide on image quality in myocardial perfusion imaging. Nuclear Medicine Communications, 33 (10). pp. 1053-1057.


Download (62kB) | Preview
Official URL:


Background: The effectiveness of metoclopramide in reducing gastrointestinal-induced artifacts in myocardial perfusion imaging (MPI) is a subject of debate. We examined the significance of this pharmacological intervention in the quality of images obtained from MPI studies. Patients and Methods: A total of 211 suspected or known cases with coronary artery disease routinely referred to our nuclear medicine department for MPI were randomly assigned to group A and group B. Group A (N=125) comprised patients who received 10 mg of metoclopramide orally after the injection of the radiotracer technetium-99m-labeled methoxyisobutyl isonitril (Tc-MIBI) 1 h before image acquisition, and group B (N=86) comprised patients who did not receive any pharmacological intervention and were considered the control group. All the scans in each group were assessed in the rest phase of a routine 2-day protocol. The single-photon emission computerized tomography (SPECT) images were visually evaluated in terms of extracardiac activities and their effects on image quality by three nuclear medicine physicians, who were blinded to the details of the protocol. Results: Of the 125 patients who had received metoclopramide, 16 (13%) had nonacceptable, 72 (57.6%) had acceptable (interpretable), and 37 (29.6%) had good image quality. The image quality in group B was nonacceptable in 10 (11.23%), acceptable in 48 (50.23%), and good in 28 (33.56%) patients. The overall interobserver agreement was good (κ: 0.6-0.9, P<0.05) among the three readers. Conclusion: There was no statistically significant difference in terms of MPI-SPECT image quality between patients who received metoclopramide and those in the control group. Metoclopramide, therefore, did not exert a remarkable effect on the quality of our MPI scans. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: methoxy isobutyl isonitrile technetium tc 99m; metoclopramide, adult; article; artifact; artifact reduction; computed tomography scanner; controlled study; coronary artery disease; drug effect; female; human; image analysis; image processing; image quality; major clinical study; male; myocardial perfusion imaging; randomized controlled trial; single blind procedure; single photon emission computer tomography, Artifacts; Female; Humans; Male; Metoclopramide; Middle Aged; Myocardial Perfusion Imaging; Quality Control
Subjects: WG Cardiovascular System
QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 06 Jan 2019 10:35
Last Modified: 06 Jan 2019 10:35

Actions (login required)

View Item View Item