Shamsian, B.S. and Abdar Esfahani, S. and Milani, H. and Akhlaghpoor, S. and Mojtahedzadeh, S. and Karimi, A. and Shamshiri, A.R. and Alavi, S. and Safari, A. and Rezaei, N. and Arzanian, M.T. (2012) Magnetic resonance imaging in the evaluation of iron overload: A comparison of MRI, echocardiography and serum ferritin level in patients with β-thalassemia major. Clinical Imaging, 36 (5). pp. 483-488.
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Abstract
Purpose: This study aimed to evaluate iron levels in cardiac and hepatic tissues using magnetic resonance imaging (MRI) T2*. Methods: Cardiac and hepatic MRI was performed for 93 patients with β-thalassemia major. Results: Cardiac T2* was in the range of 2.9-56.6 ms. Myocardial siderosis was detected in 44 of patients; 25 patients had moderate and severe siderosis with serum ferritin level (SFL) of 576-10,284 ng/ml. There was a significant correlation between SFL and cardiac T2* (p<.001). Conclusions: The effective role of MRI as a noninvasive producible method in measurement of iron concentration in tissues is not accessible with conventional techniques. © 2012 Elsevier Inc.
| Item Type: | Article |
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| Additional Information: | cited By 9 |
| Uncontrolled Keywords: | Conventional techniques; Hepatic tissue; Iron concentrations, Body fluids; Echocardiography; Histology; Iron; Liver; Magnetic resonance imaging; Tissue, Heart, deferiprone; deferoxamine; ferritin, adolescent; adult; age; article; blood transfusion; cardiovascular magnetic resonance; child; controlled study; diagnostic imaging; echocardiography; female; ferritin blood level; heart hemosiderosis; hemochromatosis; histopathology; human; human tissue; intermethod comparison; iron chelation; iron overload; iron storage; liver biopsy; liver level; major clinical study; male; nuclear magnetic resonance imaging; priority journal; school child; thalassemia major, Adolescent; Adult; beta-Thalassemia; Biological Markers; Biopsy; Chelation Therapy; Chi-Square Distribution; Child; Echocardiography; Enzyme-Linked Immunosorbent Assay; Female; Ferritins; Hepatitis C; Humans; Iron Overload; Magnetic Resonance Imaging; Male; Polymerase Chain Reaction; Statistics, Nonparametric; Treatment Outcome |
| Subjects: | WN Radiology. Diagnostic Imaging |
| Divisions: | School of Rehabilitation Sciences |
| Depositing User: | parto mrs bakhtminoo |
| Date Deposited: | 06 Jan 2019 10:41 |
| Last Modified: | 06 Jan 2019 10:41 |
| URI: | http://eprints.iums.ac.ir/id/eprint/9881 |
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